The wonderful advances and exciting perspective of theoretical physics are like a jigsaw puzzle. When presented with the unknown, scientists will argue there are still pieces to find, to fit in, but they are working on it, (they have been saying this for centuries.) What they do not perceive is that the jigsaw puzzle needs a board to fit the pieces into, a table for the board to rest on. This, since they are unaware of the limitations of the tools available to physicists, is invisible to the scientists and so the limitations of their knowledge is not apparent.
There are tools available to those who seek to know, mental tools whose existence is mentioned in historical texts, tools which if consistently applied lead to reproducible results.
Without a feeling of spaciousness which an awareness of one's ignorance allows, the real questions cannot be addressed.