This report on current research was exciting. Jan Cox based his 20th century work school on the necessity for the new. He did mention also, that you could not alter your genetic makeup. In this context I found the article excerpted below, interesting.
From an article in the OUP blog
Experiments with rodents indicate that normal cognitive processes can also initiate epigenetic events. For instance, when we encounter novelty in the world, we register it with structural changes in our brains, changes that require epigenetically controlled protein production. Storing information in long-term memory also appears to utilize epigenetic mechanisms. Thus, the way we think is affected by epigenetics, just as epigenetic factors affect the way we feel when we find ourselves in stress-inducing situations....
Some things not addressed by the writer:
Surely if you talk about change you must address what does not change. How else measure change? And also --- if you do not understand the question, how can you answer it. These are just thoughts this essay brought to mind.